N-(4-Chlorophenyl)-7-[(6,7-Dimethoxyquinolin-4-Yl)oxy]-2,3-Dihydro-1,4-Benzoxazine-4-Carboxamide

• 常用名: N-(4-Chlorophenyl)-7-[(6,7-Dimethoxyquinolin-4-Yl)oxy]-2,3-Dihydro-1,4-Benzoxazine-4-Carboxamide
• 英文名: N-(4-Chlorophenyl)-7-[(6,7-Dimethoxyquinolin-4-Yl)oxy]-2,3-Dihydro-1,4-Benzoxazine-4-Carboxamide
• CAS号: 861879-15-4
• 分子量: 491.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₂ClN₃O₅
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(4-Chlorophenyl)-7-[(6,7-Dimethoxyquinolin-4-Yl)oxy]-2,3-Dihydro-1,4-Benzoxazine-4-Carboxamide

物理化学性质

• 分子式: C₂₆H₂₂ClN₃O₅
• 分子量: 491.9
• InChIKey: RNHWXYKRVZUXGO-UHFFFAOYSA-N
• SMILES: COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(Cl)cc3)c2cc1OC

靶点实验

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实验名称：Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL950194

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL950195

实验名称：Half life in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL950196

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL950197

实验名称：Selectivity of KDR over FGFR 来源：ChEMBL 靶标：N/A External Id：CHEMBL950190

实验名称：Selectivity of KDR over Tec 来源：ChEMBL 靶标：N/A External Id：CHEMBL950191

实验名称：Metabolic stability in human liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL950192

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Metabolic stability in rat liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL950193

实验名称：Inhibition of vascular permeability in HEK293 cells over expressing mouse VEGF implan... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL950202

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