GSK-3β inhibitor 14

更新时间：2025-08-25 13:38:16

GSK-3β inhibitor 14结构式	常用名	GSK-3β inhibitor 14	英文名	GSK-3β inhibitor 14
	CAS号	863004-48-2	分子量	283.39
	密度	N/A	沸点	N/A
	分子式	C₁₇H₁₇NOS	熔点	N/A
	MSDS	N/A	闪点	N/A

GSK-3β inhibitor 14用途

GSK-3β抑制剂14(化合物6i),苯并噻嗪酮衍生物,是一种弱的GSK-3α抑制剂(IC50>100μM)[1]。

英文名	WAY-333184

描述	GSK-3β抑制剂14(化合物6i),苯并噻嗪酮衍生物,是一种弱的GSK-3α抑制剂(IC50>100μM)[1]。
相关类别	信号通路 >> 干细胞及 Wnt 通路 >> GSK-3 研究领域 >> 代谢疾病研究领域 >> 神经疾病信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
参考文献	[1]. Zhang P, et al. Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β). Eur J Med Chem. 2013 Mar;61:95-103.

分子式	C₁₇H₁₇NOS
分子量	283.39
InChIKey	NMFSTGNJEJROKR-UHFFFAOYSA-N
SMILES	CC1CC(=O)N(Cc2ccccc2)c2ccccc2S1
储存条件	-80℃储存

实验名称：Small-molecule inhibitors of ST2 (IL1RL1)
来源：20881
靶标：interleukin-1 receptor-like 1 isoform [homo sapiens]
External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：Cell-based high throughput primary assay to identify activators of GPR151
来源：The Scripps Research Institute Molecular Screening Center
靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of...
来源：The Scripps Research Institute Molecular Screening Center
靶标：N/A
External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
来源：The Scripps Research Institute Molecular Screening Center
External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Inhibition of human recombinant GSK3beta using 650HSSPHQ(pS)EDEEE as substrate after ...
来源：ChEMBL
靶标：Glycogen synthase kinase-3 beta
External Id：CHEMBL2338935

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