甲氧基X04

• 常用名: 甲氧基X04
• 英文名: Methoxy-X04
• CAS号: 863918-78-9
• 分子量: 344.40300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₀O₃
• 熔点: N/A
• 闪点: N/A

甲氧基X04用途

甲氧基-X04是一种荧光染料,可穿过血脑屏障,选择性地结合在密集核心淀粉样蛋白aβ斑块中发现的β折叠片上。

甲氧基X04名称

• 中文名: 甲氧基X04
• 英文名: methoxy-X04

甲氧基X04生物活性

• 描述: 甲氧基-X04是一种荧光染料,可穿过血脑屏障,选择性地结合在密集核心淀粉样蛋白aβ斑块中发现的β折叠片上。
• 相关类别:
  研究领域 >> 其他
• 参考文献:

  [1]. Klunk WE, Bacskai BJ, Mathis CA, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002;61(9):797-805. doi:10.1093/jnen/61.9.797

  [2]. Bisht K, El Hajj H, Savage JC, Sánchez MG, Tremblay MÈ. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016;(112):54060. Published 2016 Jun 1.

甲氧基X04物理化学性质

• 分子式: C₂₃H₂₀O₃
• 分子量: 344.40300
• 精确质量: 344.14100
• PSA: 49.69000
• LogP: 5.44720
• InChIKey: FGYNZFHVGOFCMD-KHVHPYDTSA-N
• SMILES: COc1cc(C=Cc2ccc(O)cc2)ccc1C=Cc1ccc(O)cc1
• 储存条件: -20°C，密闭，干燥

甲氧基X04靶点实验

查看更多实验

实验名称：Binding affinity to beta-amyloid plaque in Alzheimer's disease patient brain at 100 u... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243718

实验名称：Selectivity ratio of IC50 for amyloid beta (1 to 40) aggregate to IC50 for tau aggreg... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2187910

实验名称：Binding affinity to beta-amyloid plaque in Alzheimer's disease patient brain at 10 uM... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243720

实验名称：Binding affinity to beta-amyloid plaque in APP/PS1 transgenic mouse brain at 100 uM b... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243719

实验名称：Binding affinity to fibrillar amyloid beta (1 to 40) (unknown origin) assessed as flu... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243722

实验名称：Binding affinity to beta-amyloid plaque in APP/PS1 transgenic mouse brain at 1 uM by ... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243721

实验名称：Displacement of thiazene red from tau aggregate 来源：ChEMBL 靶标：Microtubule-associated protein tau External Id：CHEMBL2187911

实验名称：Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origi... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243724

实验名称：Displacement of thiazene red from amyloid beta (1 to 40) aggregate 来源：ChEMBL 靶标：N/A External Id：CHEMBL2187912

实验名称：Binding affinity to fibrillar amyloid beta (1 to 40) (unknown origin) assessed as flu... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3243723

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甲氧基X04英文别名

• m-methoxy-trans-β-nitrostyrene
• 1,4-bis (4''-hydroxystyrl)-2-methoxybenzene
• (E,E)-1-methoxy-2,5-bis(4-hydroxy)styrylbenzene