KKL-40

• 常用名: KKL-40
• 英文名: KKL-40
• CAS号: 865285-47-8
• 分子量: 351.255
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₆H₉F₄N₃O₂
• 熔点: N/A
• 闪点: N/A

KKL-40用途

一种细菌核糖体拯救的小分子抑制剂,对液体培养中生长的细菌具有广谱抗菌活性；在体外对F.tularensis(Schu S4)的减毒(LVS)和完全毒力菌株均表现出优异的抗菌活性,MIC为0.12分别为0.44微克/毫升；在感染的所有阶段阻止土拉弗朗西斯菌的细胞内生长,不影响巨噬细胞的活力或功能。

KKL-40名称

• 英文名: N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide

KKL-40生物活性

• 描述: 一种细菌核糖体拯救的小分子抑制剂,对液体培养中生长的细菌具有广谱抗菌活性；在体外对F.tularensis(Schu S4)的减毒(LVS)和完全毒力菌株均表现出优异的抗菌活性,MIC为0.12分别为0.44微克/毫升；在感染的所有阶段阻止土拉弗朗西斯菌的细胞内生长,不影响巨噬细胞的活力或功能。
• 参考文献: References 1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. View Related Products by Target Bacterial

KKL-40物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₆H₉F₄N₃O₂
• 分子量: 351.255
• 精确质量: 351.063080
• LogP: 4.43
• InChIKey: AFCDUJHJWVOHTF-UHFFFAOYSA-N
• SMILES: O=C(Nc1nnc(-c2ccc(F)cc2)o1)c1cccc(C(F)(F)F)c1
• 折射率: 1.570

KKL-40靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NT... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1640440

实验名称：Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 29213... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1640441

实验名称：Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33592... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1640593

实验名称：Antimicrobial activity against Pseudomonas aeruginosa ATCC 25619 after 18 to 24 hrs b... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1640426

实验名称：Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stim... 来源：ChEMBL 靶标：Adenylate cyclase type 8 External Id：CHEMBL4384518

实验名称：Antimicrobial activity against methicillin resistant Staphylococcus aureus A252 asses... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5241555

实验名称：Antimicrobial activity against Acinetobacter baumannii ATCC 49139 after 18 to 24 hrs ... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL1640427

实验名称：Antimicrobial activity against Staphylococcus aureus Newman assessed as inhibition of... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5241554

实验名称：Antimicrobial activity against Stenotrophomonas maltophilia ATCC 13637 after 18 to 24... 来源：ChEMBL 靶标：Stenotrophomonas maltophilia External Id：CHEMBL1640428

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KKL-40英文别名

• N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide