I942

• 常用名: I942
• 英文名: I942
• CAS号: 868145-09-9
• 分子量: 369.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉NO₄S
• 熔点: N/A
• 闪点: N/A

I942用途

I942是EPAC1的第一类非环状核苷酸激动剂。

I942名称

• 英文名: I942

I942生物活性

• 描述: I942是EPAC1的第一类非环状核苷酸激动剂。
• 参考文献: 1. Barker G, Parnell E, van Basten B, Buist H, Adams DR, Yarwood SJ. The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation. J Cardiovasc Dev Dis. 2017 Dec 5;4(4). pii: E22. doi: 10.3390/jcdd4040022. Review. PubMed PMID: 29367551; PubMed Central PMCID: PMC5753123.

I942物理化学性质

• 分子式: C₂₀H₁₉NO₄S
• 分子量: 369.43
• InChIKey: KCRXXSQZEZOCFM-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)NC(=O)COc2ccc3ccccc3c2)c(C)c1

I942靶点实验

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实验名称：Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown ... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4346466

实验名称：Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by meas... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4346477

实验名称：Activation of EPAC1 (unknown origin) expressed in U2OS cells at 100 uM incubated for ... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4346476

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues)expressed in Esc... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4605947

实验名称：Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues)expressed in Esc... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4605946

实验名称：Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues)expressed in Esc... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4605949

实验名称：Activity at EPAC1 in HUVEC assessed as promotion of IL-6-promoted signaling by measur... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4346483

实验名称：Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues)expressed in Esc... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4605948

实验名称：Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by meas... 来源：ChEMBL 靶标：Rap guanine nucleotide exchange factor 3 External Id：CHEMBL4346480

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