JNJ-26489112

• 常用名: JNJ-26489112
• 英文名: JNJ-26489112
• CAS号: 871824-55-4
• 分子量: 278.713
• 密度: 1.5±0.1 g/cm3
• 沸点: 457.8±55.0 °C at 760 mmHg
• 分子式: C₉H₁₁ClN₂O₄S
• 熔点: N/A
• 闪点: 230.7±31.5 °C

JNJ-26489112用途

JNJ-26489112(JNJ26489112)是一种广谱抗惊厥药,在啮齿动物中显示出对抗听力,电诱导和化学诱导的癫痫发作的活性；对人CA-II的抑制作用非常弱(IC50=35μM)；抑制Na+,红藻氨酸盐和KCNQ2渠道不同程度,虽然适度增强GABA电流并抑制N-甲基-D-天冬氨酸电流,但其在几个靶标上的作用似乎是观察到的神经稳定作用的原因；在临床前动物模型中显示有限的癫痫发作扩散和升高的癫痫发作阈值。癫痫停止了

JNJ-26489112名称

• 英文名: JNJ-26489112

JNJ-26489112生物活性

• 描述: JNJ-26489112(JNJ26489112)是一种广谱抗惊厥药,在啮齿动物中显示出对抗听力,电诱导和化学诱导的癫痫发作的活性；对人CA-II的抑制作用非常弱(IC50=35μM)；抑制Na+,红藻氨酸盐和KCNQ2渠道不同程度,虽然适度增强GABA电流并抑制N-甲基-D-天冬氨酸电流,但其在几个靶标上的作用似乎是观察到的神经稳定作用的原因；在临床前动物模型中显示有限的癫痫发作扩散和升高的癫痫发作阈值。癫痫停止了
• 参考文献: References 1. McComsey DF, et al. J Med Chem. 2013 Nov 27;56(22):9019-30. View Related Products by Target Other Targets Epilepsy

JNJ-26489112物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 457.8±55.0 °C at 760 mmHg
• 分子式: C₉H₁₁ClN₂O₄S
• 分子量: 278.713
• 闪点: 230.7±31.5 °C
• 精确质量: 278.012817
• LogP: 1.03
• InChIKey: KXSAIQPPGSSNKX-ZETCQYMHSA-N
• SMILES: NS(=O)(=O)NCC1COc2cc(Cl)ccc2O1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.597

JNJ-26489112靶点实验

查看更多实验

实验名称：Neurotoxicity in po dosed Sprague-Dawley rat by rotarod test 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3097729

实验名称：Neurotoxicity in ip dosed Sprague-Dawley rat by rotarod test 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3097911

实验名称：Anticonvulsant activity in ip dosed CF-1 mouse assessed as protection against maximal... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3097912

实验名称：Anticonvulsant activity in ip dosed CF-1 mouse assessed as protection against subcuta... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3097916

实验名称：Anticonvulsant activity in ip dosed CF-1 mouse assessed as protection against subcuta... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3097917

实验名称：Anticonvulsant activity in ip dosed CF-1 mouse assessed as protection against subcuta... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3097918

实验名称：Anticonvulsant activity in po dosed Sprague-Dawley rat assessed as protection against... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3097921

实验名称：Anticonvulsant activity in ip dosed Sprague-Dawley rat hippocampal kindling model ass... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3097716

实验名称：Anticonvulsant activity in ip dosed Sprague-Dawley rat hippocampal kindling model ass... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3097717

实验名称：Anticonvulsant activity in ip dosed Sprague-Dawley rat hippocampal kindling model ass... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3097718

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JNJ-26489112英文别名

• N-{[(2S)-6-Chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}sulfuric diamide
• JNJ-26489112
• G1TI012DLT