Ar-c141990

• 常用名: Ar-c141990
• 英文名: Ar-c141990
• CAS号: 873327-59-4
• 分子量: 492.59
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₈N₄O₄S
• 熔点: N/A
• 闪点: N/A

Ar-c141990用途

AR-C141990是一种乳酸转运蛋白抑制剂。

Ar-c141990名称

• 英文名: AR-C141990

Ar-c141990生物活性

• 描述: AR-C141990是一种乳酸转运蛋白抑制剂。
• 参考文献: 1. Thiesen L, Kehler J, Clausen RP, Frølund B, Bundgaard C, Wellendorph P. In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1. J Pharmacol Exp Ther. 2015 Aug;354(2):166-74. doi: 10.1124/jpet.115.224543. Epub 2015 May 18. PubMed PMID: 25986445.

Ar-c141990物理化学性质

• 分子式: C₂₆H₂₈N₄O₄S
• 分子量: 492.59
• InChIKey: JOFQERPJMGKMMX-QGZVFWFLSA-N
• SMILES: CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N3CCC(O)C3)c(Cc3ccnc4ccccc34)sc21

Ar-c141990靶点实验

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实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Antiproliferative activity against human PBMC assessed as inhibition of PMA/ionomycin... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL1226678

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301367

实验名称：Intrinsic clearance in human hepatocytes measured as per 10^6 cells 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL869595

实验名称：ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301370

实验名称：Binding affinity to MCT1 来源：ChEMBL 靶标：Monocarboxylate transporter 1 External Id：CHEMBL910522

实验名称：Inhibition of CYP2C9 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL869596

实验名称：Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-... 来源：ChEMBL 靶标：Monocarboxylate transporter 1 External Id：CHEMBL1226686

实验名称：Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-... 来源：ChEMBL 靶标：Monocarboxylate transporter 1 External Id：CHEMBL1226685

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