4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-(6-methoxypyridin-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

• 常用名: 4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-(6-methoxypyridin-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide
• 英文名: 4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-(6-methoxypyridin-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide
• CAS号: 874119-57-0
• 分子量: 490.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₀ClFN₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-(6-methoxypyridin-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

物理化学性质

• 分子式: C₂₅H₂₀ClFN₆O₂
• 分子量: 490.9
• InChIKey: ZKNOJWWMOBXREH-UHFFFAOYSA-N
• SMILES: COc1ccc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cn1

靶点实验

查看更多实验

实验名称：Inhibition of human recombinant ROCK1 kinase expressed in insect Sf9 cells by SPA 来源：ChEMBL 靶标：Rho-associated protein kinase 1 External Id：CHEMBL987092

实验名称：Inhibition of CYP2D6 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL986249

实验名称：ROCK Kinase Inhibition Assay from Article 10.1021/jm8005096: "Potent, selective and o... 来源：BindingDB 靶标：N/A External Id：BindingDB_2865_1

实验名称：Inhibition of CYP3A4 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL986246

实验名称：Oral bioavailability in Sprague-Dawley rat at 1.1 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL986229

共5条，当前第1页，共1页

1