MLS1082

• 常用名: MLS1082
• 英文名: MLS1082
• CAS号: 883958-36-9
• 分子量: 385.458
• 密度: 1.3±0.1 g/cm3
• 沸点: 520.1±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₃N₃O₂
• 熔点: N/A
• 闪点: 268.4±32.9 °C

MLS1082用途

MLS1082是D1多巴胺受体的新型正变构调节剂,增强多巴胺刺激的G蛋白和β-抑制蛋白介导的信号传导,并增加多巴胺对具有低微摩尔效力的D1受体的亲和力。

MLS1082名称

• 英文名: 2-Cyclohexyl-10-methyl-3-phenyl-3H,10H-pyrimido[4,5-b]quinoline-4,5-dione

MLS1082生物活性

• 描述: MLS1082是D1多巴胺受体的新型正变构调节剂,增强多巴胺刺激的G蛋白和β-抑制蛋白介导的信号传导,并增加多巴胺对具有低微摩尔效力的D1受体的亲和力。
• 参考文献: References 1. Luderman KD, et al. Mol Pharmacol. 2018 Aug 1. pii: mol.118.113175. View Related Products by Target Dopamine Receptor

MLS1082物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 520.1±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₃N₃O₂
• 分子量: 385.458
• 闪点: 268.4±32.9 °C
• 精确质量: 385.179016
• LogP: 2.78
• InChIKey: HZGMAMIIHBRAAR-UHFFFAOYSA-N
• SMILES: Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.688

MLS1082靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL4677860

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MLS1082英文别名

• 2-Cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
• 2-Cyclohexyl-10-methyl-3-phenyl-3H,10H-pyrimido[4,5-b]quinoline-4,5-dione