2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide

• 常用名: 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
• 英文名: 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
• CAS号: 888854-97-5
• 分子量: 422.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₆F₂N₄O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide

物理化学性质

• 分子式: C₂₂H₁₆F₂N₄O₃
• 分子量: 422.4
• InChIKey: BMPOCDJEXAXXEZ-UHFFFAOYSA-N
• SMILES: O=C(Cc1ccc(F)cc1)NC(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1

靶点实验

查看更多实验

实验名称：Inhibition of Met kinase 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL953404

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：AUC (0 to 4 hrs) in mouse at 50 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL953411

实验名称：Cmax in mouse at 50 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL953409

实验名称：Tmax in mouse at 50 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL953410

实验名称：Metabolic stability in human liver microsomes at 3 uM after 10 mins 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL953407

实验名称：Inhibition of human c-MET 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL1826790

实验名称：Metabolic stability in mouse liver microsomes at 3 uM after 10 mins 来源：ChEMBL 靶标：N/A External Id：CHEMBL953408

实验名称：Antiproliferative activity against human GTL16 cells 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL953405

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