3-(4-Chlorophenyl)-9-(2-propyn-1-ylamino)pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one

• 常用名: 3-(4-Chlorophenyl)-9-(2-propyn-1-ylamino)pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one
• 英文名: 3-(4-Chlorophenyl)-9-(2-propyn-1-ylamino)pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one
• CAS号: 902747-93-7
• 分子量: 366.8
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₁ClN₄OS
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 3-(4-Chlorophenyl)-9-(2-propyn-1-ylamino)pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one

物理化学性质

• 分子式: C₁₈H₁₁ClN₄OS
• 分子量: 366.8
• InChIKey: MAYHTEHJUHRFSA-UHFFFAOYSA-N
• SMILES: C#CCNc1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12

靶点实验

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实验名称：Rat mGlu1 receptor (Metabotropic glutamate receptors) 来源：IUPHAR-DB 靶标：mGlu1 receptor (Metabotropic glutamate receptors) [Rattus norvegicus] External Id：289_Rat

实验名称：Drug level in rat brain at 10 mg/kg measured at 6 hrs post dose 来源：ChEMBL 靶标：Brain External Id：CHEMBL1786750

实验名称：AUC in rat 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1786749

实验名称：Ratio of drug level in brain to plasma in rat at 10 mg/kg 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL1786751

实验名称：Human mGlu1 receptor (Metabotropic glutamate receptors) 来源：IUPHAR-DB 靶标：mGlu1 receptor (Metabotropic glutamate receptors) [Homo sapiens] External Id：289_Human

实验名称：Antagonist activity at rat mGluR1 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL1786744

实验名称：Antagonist activity at human mGluR1 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL1786743

实验名称：Inhibition of neuropathic pain in po dosed rat spinal nerve ligation model 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1786746

实验名称：Antagonist activity at human mGluR5 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL1786745

实验名称：Drug efflux assessed as P-gp-mediated efflux by efflux substrate assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1786748

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