A-908292

更新时间：2025-08-24 17:00:30

A-908292用途

A-908292是一种高效、选择性的乙酰辅酶A羧化酶2(ACC2)抑制剂,IC50为38 nM(hACC2),对ACC1无活性(IC50>30μm)。

英文名	A-908292

描述	A-908292是一种高效、选择性的乙酰辅酶A羧化酶2(ACC2)抑制剂,IC50为38 nM(hACC2),对ACC1无活性(IC50>30μm)。
参考文献	1. Nishiura Y, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503. 2. Takagi H, et al. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263. 3. Waring JF, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16.

分子式	C₁₈H₂₀N₂O₄S
分子量	360.428
InChIKey	OLMPAYQFDVALIH-ZDUSSCGKSA-N
SMILES	COC(=O)NC(C)C#Cc1cnc(Oc2ccc(OC(C)C)cc2)s1

实验名称：Reduction of mCoA level in Sprague-Dawley rat muscle at 10 mg/kg, po
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL867463

实验名称：Reduction of mCoA level in Sprague-Dawley rat muscle at 50 mg/kg, po
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL867465

实验名称：Inhibition of human recombinant ACC1 expressed in HEK293 cells
来源：ChEMBL
靶标：Acetyl-CoA carboxylase 1
External Id：CHEMBL916199

实验名称：Inhibition of human recombinant ACC2 expressed in SF9 cells
来源：ChEMBL
靶标：Acetyl-CoA carboxylase 2
External Id：CHEMBL916200

实验名称：Selectivity for human ACC2 over ACC1
来源：ChEMBL
靶标：N/A
External Id：CHEMBL915186

实验名称：Seizure activity in iv dosed anesthetized rat
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL916203

实验名称：Ratio of drug level in rat brain against plasma
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL916206

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3301365

实验名称：Reduction of mCoA level in Sprague-Dawley rat liver at 50 mg/kg, po
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL867467

实验名称：Drug concentration in Sprague-Dawley rat plasma at 10 mg/kg
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL867468

共20条，当前第1页，共2页

查看所有供应商和价格请点击：