Methanone, (1,3-dihydro-5-(tetrahydro-2H-pyran-4-yl)-2H-isoindol-2-yl)(5-(methylsulfonyl)-2-((1S)-2,2,2-trifluoro-1-methylethoxy)phenyl)

• 常用名: Methanone, (1,3-dihydro-5-(tetrahydro-2H-pyran-4-yl)-2H-isoindol-2-yl)(5-(methylsulfonyl)-2-((1S)-2,2,2-trifluoro-1-methylethoxy)phenyl)
• 英文名: Methanone, (1,3-dihydro-5-(tetrahydro-2H-pyran-4-yl)-2H-isoindol-2-yl)(5-(methylsulfonyl)-2-((1S)-2,2,2-trifluoro-1-methylethoxy)phenyl)
• CAS号: 905272-07-3
• 分子量: 497.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₆F₃NO₅S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Methanone, (1,3-dihydro-5-(tetrahydro-2H-pyran-4-yl)-2H-isoindol-2-yl)(5-(methylsulfonyl)-2-((1S)-2,2,2-trifluoro-1-methylethoxy)phenyl)

物理化学性质

• 分子式: C₂₄H₂₆F₃NO₅S
• 分子量: 497.5
• InChIKey: IHLMQHFPWQMCHB-HNNXBMFYSA-N
• SMILES: CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(C3CCOCC3)cc2C1)C(F)(F)F

靶点实验

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实验名称：Intrinsic clearance in rat liver microsomes assessed per mg of protein 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1639785

实验名称：Induction of GlyT1-mediated glycine uptake in rat striatum assessed as increase of gl... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1639786

实验名称：Induction of GlyT1-mediated glycine uptake in rat striatum assessed as increase of gl... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1639787

实验名称：Drug level in rat plasma at 10 mg/kg after 3 hrs 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1639788

实验名称：Drug level in rat brain at 10 mg/kg after 3 hrs 来源：ChEMBL 靶标：Brain External Id：CHEMBL1639789

实验名称：Aqueous solubility of the compound by lyophilisate solubility assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1639758

实验名称：Ratio of drug uptake in rat brain to EC50 for human GlyT1 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL1639790

实验名称：Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycin... 来源：ChEMBL 靶标：Sodium- and chloride-dependent glycine transporter 1 External Id：CHEMBL1639759

实验名称：Inhibition of human GlyT2 expressed in CHO cells assessed as inhibition of [3H]glycin... 来源：ChEMBL 靶标：Sodium- and chloride-dependent glycine transporter 2 External Id：CHEMBL1639760

实验名称：Terminal half life in rat at 6.8 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1639779

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