NSC49652

• 常用名: NSC49652
• 英文名: NSC49652
• CAS号: 908563-68-8
• 分子量: 225.243
• 密度: 1.2±0.1 g/cm3
• 沸点: 414.3±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₁NO₂
• 熔点: N/A
• 闪点: 204.4±28.7 °C

NSC49652用途

NSC49652(NSC 49652)是一种靶向死亡受体p75NTR的跨膜结构域(TMD)的化合物,在AraTM测定中IC50为10μM,改变p75NTR TMD的相对构象并诱导哺乳动物细胞中全长受体的动态变化；通过p75NTR和神经元中的JNK途径诱导细胞凋亡并影响黑素瘤细胞的活力,减少肿瘤生长并改善口服的人黑素瘤异种移植模型中的存活。

NSC49652名称

• 中文名: (2E)-1-(2-羟基苯基)-3-(吡啶-3-基)丙-2-烯-1-酮
• 英文名: (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one

NSC49652生物活性

• 描述: NSC49652(NSC 49652)是一种靶向死亡受体p75NTR的跨膜结构域(TMD)的化合物,在AraTM测定中IC50为10μM,改变p75NTR TMD的相对构象并诱导哺乳动物细胞中全长受体的动态变化；通过p75NTR和神经元中的JNK途径诱导细胞凋亡并影响黑素瘤细胞的活力,减少肿瘤生长并改善口服的人黑素瘤异种移植模型中的存活。
• 参考文献: References 1. Goh ETH, et al. Cell Chem Biol. 2018 Oct 1. pii: S2451-9456(18)30302-7. View Related Products by Target Trk Receptor

NSC49652物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 414.3±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₁NO₂
• 分子量: 225.243
• 闪点: 204.4±28.7 °C
• 精确质量: 225.078979
• LogP: 2.76
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.661
• 储存条件: 2-8°C

NSC49652靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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NSC49652英文别名

• (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one
• MFCD00499170