Inflachromene

• 常用名: Inflachromene
• 英文名: Inflachromene
• CAS号: 908568-01-4
• 分子量: 377.393
• 密度: 1.5±0.1 g/cm3
• 沸点: 532.6±60.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉N₃O₄
• 熔点: N/A
• 闪点: 275.9±32.9 °C

Inflachromene用途

Inflachromene(ICM)是一种具有抗炎作用的小胶质细胞抑制剂,可直接结合高迁移率族蛋白1(HMGB1)和HMGB2,减少其在小胶质细胞中的细胞质积累；通过扰乱其翻译后修饰阻断HMGBs的细胞质定位和细胞外释放的连续过程；有效下调HMGB的促炎功能并减少体内神经元损伤。

Inflachromene名称

• 中文名: Inflachromene
• 英文名: Inflachromene

Inflachromene生物活性

• 描述: Inflachromene(ICM)是一种具有抗炎作用的小胶质细胞抑制剂,可直接结合高迁移率族蛋白1(HMGB1)和HMGB2,减少其在小胶质细胞中的细胞质积累；通过扰乱其翻译后修饰阻断HMGBs的细胞质定位和细胞外释放的连续过程；有效下调HMGB的促炎功能并减少体内神经元损伤。
• 参考文献: References 1. Lee S, et al. Nat Chem Biol. 2014 Dec;10(12):1055-60. 2. Cho W, et al. J Med Chem. 2017 Jan 12;60(1):170-179. View Related Products by Target Other Targets

Inflachromene物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 532.6±60.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉N₃O₄
• 分子量: 377.393
• 闪点: 275.9±32.9 °C
• 精确质量: 377.137543
• LogP: 1.86
• InChIKey: VVOXDJYPDCSQMI-UHFFFAOYSA-N
• SMILES: CC1(C)Oc2cc(O)ccc2C2C1=CCn1c(=O)n(-c3ccccc3)c(=O)n12
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.747
• 储存条件: -20°C，密闭，干燥

Inflachromene靶点实验

查看更多实验

实验名称：Anti-inflammatory activity in C57BL/6(B6) mouse model of CLP-induced sepsis assessed ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4042722

实验名称：Anti-inflammatory activity in C57BL/6(B6) mouse model of CLP-induced sepsis assessed ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4042723

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 30 uM after d... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1806179

实验名称：Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as TR... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1806178

实验名称：Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as de... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1806181

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 30 uM after d... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1806180

实验名称：Inhibition of NFkappa signaling in mouse RAW264.7 cells assessed as reduction in RANK... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1806183

实验名称：Inhibition of RANKL-induced osteoclastogenesis in BALB/c mouse Bone marrow macrophage... 来源：ChEMBL 靶标：Macrophage External Id：CHEMBL1806182

实验名称：Inhibition of c-Src mRNA expression in mouse RAW264.7 cells at 10 uM by RT-PCR analys... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1806185

实验名称：Anti-inflammatory activity in C57BL/6(B6) mouse model of CLP-induced sepsis assessed ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4042744

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Inflachromene英文别名

• Inflachromene
• 10-Hydroxy-7,7-dimethyl-2-phenyl-5,12b-dihydro-1H,7H-chromeno[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione