ISX-1

• 常用名: ISX-1
• 英文名: ISX-1
• CAS号: 909207-35-8
• 分子量: 302.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₄N₄O₂S
• 熔点: N/A
• 闪点: N/A

ISX-1用途

ISX-1是异恶唑。ISX-1具有抗脂肪生成和促成骨活性。ISX-1可用于骨质减少和骨质疏松症的研究[1]。

ISX-1名称

• 英文名: ISX-1

ISX-1生物活性

• 描述: ISX-1是异恶唑。ISX-1具有抗脂肪生成和促成骨活性。ISX-1可用于骨质减少和骨质疏松症的研究[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 1.9 μM (lipid droplet formation); EC50: 1.2 μM (induce ALP)[1]

• 体外研究: 是x-1剂量依赖性地抑制细胞内脂滴的积累并刺激 阿尔卑斯山活性[1]。 是x-1可形成脂滴,国际50值为 1.9μ也可诱导 阿尔卑斯山,EC50值为 1.2μM[1]ISX-1(0、1.3、6.5和 33μM3.天)抑制 人骨髓基质干细胞成脂分化过程中 PPARγ和 制造厂4基因的 mRNA表达诱导[1]。 ISX-1(0、1.3、6.5和 33微米)促进 TCF/LEF介导的基因转录[1]。 RT-PCR[1]细胞系：人骨髓间充质干细胞(hBMSCs)浓度：0、1.3、6.5和33μM培养时间：3天结果：抑制了hBMSCs脂肪分化过程中PPARγ和FABP4基因的mRNA诱导,对C/EBPα表达无影响。Western Blot分析[1]细胞系：HEK 293细胞浓度：6.5和33μM孵育时间：6.5和30μM结果：激活的β-。
• 参考文献:

  [1]. Nawa, Katsuhiko et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74.

ISX-1物理化学性质

• 分子式: C₁₄H₁₄N₄O₂S
• 分子量: 302.35
• InChIKey: LRGVDHZAEYAHLG-UHFFFAOYSA-N
• SMILES: O=C(NCCCn1ccnc1)c1cc(-c2cccs2)on1

ISX-1靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Fluorescent Cell-Based Secondary Screen to Identify Activators of the Hypoxia Factor ... 来源：Broad Institute 靶标：N/A External Id：2030-03_ACTIVATORS_DOSE-TITRATION_MLPCN-CHERRYPICK

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：HTS to identify inhibitors of Caspase inhibitor (zVAD) Induced Cell Death in L929 Cel... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：N/A External Id：HTS to identify inhibitors of Caspase Inhibitor (zVAD) Induced Cell Death in L929 Cells: Confirmation Assays, MH81266

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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