1,1-Cyclopropanedicarboxamide, N-[4-[[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy]-3-fluorophenyl]-N'-phenyl

• 常用名: 1,1-Cyclopropanedicarboxamide, N-[4-[[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy]-3-fluorophenyl]-N'-phenyl
• 英文名: 1,1-Cyclopropanedicarboxamide, N-[4-[[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy]-3-fluorophenyl]-N'-phenyl
• CAS号: 918640-54-7
• 分子量: 541.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₄FN₅O₃S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1,1-Cyclopropanedicarboxamide, N-[4-[[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy]-3-fluorophenyl]-N'-phenyl

物理化学性质

• 分子式: C₂₉H₂₄FN₅O₃S
• 分子量: 541.6
• InChIKey: QATOHKJFHXOHIB-UHFFFAOYSA-N
• SMILES: CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccccc6)CC5)cc4F)c3s2)c1

靶点实验

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实验名称：Inhibition of GST-fused recombinant VEGFR2 expressed in baculovirus infected Sf9 cell... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL1050654

实验名称：Cmax in rat at 4.28 to 4.98 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1050661

实验名称：AUC in rat at 4.28 to 4.98 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1050662

实验名称：Volume of distribution at steady state in rat at 2.17 to 2.86 mg/kg, iv and 4.28 to 4... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1050659

实验名称：Tmax in rat at 4.28 to 4.98 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1050660

实验名称：Half life in rat at 2.17 to 2.86 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1050657

实验名称：Clearance in rat at 2.17 to 2.86 mg/kg, iv and 4.28 to 4.98 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1050658

实验名称：Inhibition of GST-fused recombinant C-met expressed in baculovirus infected high five... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL1050655

实验名称：Inhibition of TPR-met autophosphorylation expressed in HEK293T cells after 150 mins b... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL1050656

实验名称：Antitumor activity against human A549 cells xenografted model assessed as tumor growt... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1050669

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