9H-Purine, 9-b-D-arabinofuranosyl-6-methoxy

• 常用名: 9H-Purine, 9-b-D-arabinofuranosyl-6-methoxy
• 英文名: 9H-Purine, 9-b-D-arabinofuranosyl-6-methoxy
• CAS号: 91969-06-1
• 分子量: 282.25300
• 密度: 1.84g/cm3
• 沸点: 610.7ºC at 760mmHg
• 分子式: C₁₁H₁₄N₄O₅
• 熔点: N/A
• 闪点: 323.1ºC

用途

6-Methoxypurine arabinoside (Ara-m) 是一种有效的水痘-带状疱疹病毒抑制剂。6-Methoxypurine arabinoside 对8株VZV具有50%的抑制浓度,范围为0.5-3 microM。

名称

• 英文名: (2R,3S,4S,5R)-2-(hydroxymethyl)-5-(6-methoxypurin-9-yl)oxolane-3,4-diol

生物活性

• 描述: 6-Methoxypurine arabinoside (Ara-m) 是一种有效的水痘-带状疱疹病毒抑制剂。6-Methoxypurine arabinoside 对8株VZV具有50%的抑制浓度,范围为0.5-3 microM。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Averett DR, et al. 6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus. Antimicrob Agents Chemother. 1991 May;35(5):851-7.

物理化学性质

• 密度: 1.84g/cm3
• 沸点: 610.7ºC at 760mmHg
• 分子式: C₁₁H₁₄N₄O₅
• 分子量: 282.25300
• 闪点: 323.1ºC
• 精确质量: 282.09600
• PSA: 122.75000
• InChIKey: UQQHOWKTDKKTHO-ICQCTTRCSA-N
• SMILES: COc1ncnc2c1ncn2C1OC(CO)C(O)C1O

靶点实验

查看更多实验

实验名称：Concentration required to inhibit HSV type 1 strain HF induced cytopathogenic affects... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL694222

实验名称：HPLC capacity factor (k') 来源：ChEMBL 靶标：N/A External Id：CHEMBL638343

实验名称：Ester prodrugs: stability in buffer (pH 7) 来源：ChEMBL 靶标：N/A External Id：CHEMBL633052

实验名称：In vitro antiviral activity in secondary cultures of rabbit kidney cells infected wit... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL877527

实验名称：Concentration required to inhibit vaccinia virus induced cytopathogenic affects by 50... 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL821335

实验名称：Ester prodrugs: recovery of parent compound in rat urine 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL638767

实验名称：In vitro for antiviral activity in secondary cultures of rabbit kidney cells infected... 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL821892

实验名称：Ester prodrugs: recovery of parent compound in rat urine 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL638840

实验名称：Kinetic parameter in calf intestine adenosine deaminase. 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL636142

实验名称：Molar potency ratio was evaluated 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL849749

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英文别名

• ara-M
• 6-Methoxyvidarabine
• 6-methoxypurine arabinoside