FiVe1

• 常用名: FiVe1
• 英文名: FiVe1
• CAS号: 932359-76-7
• 分子量: 359.254
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₆Cl₂N₄
• 熔点: N/A
• 闪点: N/A

FiVe1用途

FiVe1是一种波形蛋白结合小分子,在中期促进波形蛋白解体和磷酸化,导致有丝分裂灾难,多核化和癌细胞干性丧失；选择性地和不可逆地抑制间充质转化的乳腺癌细胞(FOXC2-HMLER细胞IC50=234nM)和不同组织学亚型的软组织肉瘤的生长。

FiVe1名称

• 英文名: FiVe1

FiVe1生物活性

• 描述: FiVe1是一种波形蛋白结合小分子,在中期促进波形蛋白解体和磷酸化,导致有丝分裂灾难,多核化和癌细胞干性丧失；选择性地和不可逆地抑制间充质转化的乳腺癌细胞(FOXC2-HMLER细胞IC50=234nM)和不同组织学亚型的软组织肉瘤的生长。
• 参考文献: References 1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. View Related Products by Target Microtubule/Tubulin

FiVe1物理化学性质

• 分子式: C₁₈H₁₆Cl₂N₄
• 分子量: 359.254
• InChIKey: DZGXRHIQXADSDH-UHFFFAOYSA-N
• SMILES: Clc1cccc(N2CCN(c3cnnc4c(Cl)cccc34)CC2)c1

FiVe1靶点实验

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实验名称：Half life in mouse at 25 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5353029

实验名称：Tmax in mouse at 25 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5353030

实验名称：AUC (0 to last) in mouse at 25 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5353027

实验名称：AUC (0 to infinity) in mouse at 25 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5353028

实验名称：Antiproliferative activity against human MCF7 cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5353013

实验名称：Selectivity ratio of IC50 for human MCF7 cells to IC50 for human HT-1080 来源：ChEMBL 靶标：N/A External Id：CHEMBL5353014

实验名称：Antiproliferative activity against human RD cells assessed as inhibition of cell grow... 来源：ChEMBL 靶标：RD External Id：CHEMBL5353011

实验名称：Antiproliferative activity against human GCT cells assessed as inhibition of cell gro... 来源：ChEMBL 靶标：GCT External Id：CHEMBL5353012

实验名称：Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell... 来源：ChEMBL 靶标：HT-1080 External Id：CHEMBL5353010

实验名称：Drug metabolism in mouse hepatocytes assessed as oxygenation by measuring M7 metaboli... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5353049

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