(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyrazin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one

• 常用名: (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyrazin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one
• 英文名: (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyrazin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one
• CAS号: 934343-79-0
• 分子量: 380.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₇FN₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyrazin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one

物理化学性质

• 分子式: C₁₉H₁₇FN₆O₂
• 分子量: 380.4
• InChIKey: XRFHWSYKRFEPRA-CYBMUJFWSA-N
• SMILES: COc1cncc(-c2cc(F)ccc2C2Cc3nc(N)nc(C)c3C(=O)N2)n1

靶点实验

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实验名称：Antitumor activity against human GTL16 cells xenografted in athymic nu/nu mouse asses... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3388138

实验名称：Antitumor activity against human GTL16 cells xenografted in athymic nu/nu mouse asses... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3388137

实验名称：Inhibition of N-terminal His-tagged HSP90-alpha (unknown origin) after 2 hrs by spect... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL3387537

实验名称：Inhibition of HSP90 (unknown origin) assessed as down regulation of Hsp70 after 20 hr... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL3387539

实验名称：Inhibition of HSP90 (unknown origin) assessed as down regulation of c-Met after 20 hr... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL3387538

实验名称：Cytotoxicity against human GTL16 cells after 72 hrs by CellTitre-Glo assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3387540

实验名称：Oral bioavailability in CD-1 mouse at 10 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3387542

实验名称：Half life in CD-1 mouse at 5 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3387545

实验名称：AUC (0 to last) in CD-1 mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3387544

实验名称：Clearance in CD-1 mouse at 5 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3387546

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