[3,4-Bis(Fluoranyl)-2-[(2-Fluoranyl-4-Iodanyl-Phenyl)amino]phenyl]-(3-Oxidanylazetidin-1-Yl)methanone

• 常用名: [3,4-Bis(Fluoranyl)-2-[(2-Fluoranyl-4-Iodanyl-Phenyl)amino]phenyl]-(3-Oxidanylazetidin-1-Yl)methanone
• 英文名: [3,4-Bis(Fluoranyl)-2-[(2-Fluoranyl-4-Iodanyl-Phenyl)amino]phenyl]-(3-Oxidanylazetidin-1-Yl)methanone
• CAS号: 934660-66-9
• 分子量: 448.18
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₂F₃IN₂O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: [3,4-Bis(Fluoranyl)-2-[(2-Fluoranyl-4-Iodanyl-Phenyl)amino]phenyl]-(3-Oxidanylazetidin-1-Yl)methanone

物理化学性质

• 分子式: C₁₆H₁₂F₃IN₂O₂
• 分子量: 448.18
• InChIKey: COACPTNNJAFVAN-UHFFFAOYSA-N
• SMILES: O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)C1

靶点实验

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实验名称：Dose normalised AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2149494

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Half life in Sprague-Dawley rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2149497

实验名称：Drug metabolism in human liver microsomes at 15 uM after 30 mins 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2149498

实验名称：Oral bioavailability in Sprague-Dawley rat at 5 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2149495

实验名称：Clearance in Sprague-Dawley rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2149496

实验名称：Inhibition of MEK-mediated ERK T202/Y204 phosphorylation in human MDA-MB-231T cells a... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 2 External Id：CHEMBL2149501

实验名称：Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as ... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 1 External Id：CHEMBL2149502

实验名称：Apparent permeability across MDCK cells 来源：ChEMBL 靶标：MDCK External Id：CHEMBL2149499

实验名称：Drug metabolism in rat liver microsomes at 15 uM after 30 mins 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2149500

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