QM31

• 常用名: QM31
• 英文名: QM31
• CAS号: 937735-00-7
• 分子量: 768.557
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₉H₃₈Cl₄N₄O₄
• 熔点: N/A
• 闪点: N/A

QM31用途

QM31(SVT016426,Apaf-1抑制剂QM31)是一种抑制凋亡小体形成的细胞保护剂(体外IC50=7.9 uM),由Apaf-1,细胞色素c,dATP和caspase-9组成的半胱天冬酶激活复合物；抑制Apaf-1依赖的S期内DNA损伤检查点；QM31可干扰Apaf-1的两种已知功能,即凋亡小体组装/激活和S期内细胞周期停滞。

QM31名称

• 英文名: QM31

QM31生物活性

• 描述: QM31(SVT016426,Apaf-1抑制剂QM31)是一种抑制凋亡小体形成的细胞保护剂(体外IC50=7.9 uM),由Apaf-1,细胞色素c,dATP和caspase-9组成的半胱天冬酶激活复合物；抑制Apaf-1依赖的S期内DNA损伤检查点；QM31可干扰Apaf-1的两种已知功能,即凋亡小体组装/激活和S期内细胞周期停滞。
• 参考文献: References 1. Mondragón L, et al. Apoptosis. 2009 Feb;14(2):182-90. 2. Mondragón L, et al. J Med Chem. 2008 Feb 14;51(3):521-9. 3. Malet G, et al. Cell Death Differ. 2006 Sep;13(9):1523-32. View Related Products by Target Apaf-1

QM31物理化学性质

• 分子式: C₃₉H₃₈Cl₄N₄O₄
• 分子量: 768.557
• InChIKey: YSUHYGYGQFSKDT-UHFFFAOYSA-N
• SMILES: NC(=O)CN(CCc1ccc(Cl)cc1Cl)C(=O)C1CC(=O)N(CCc2ccc(Cl)cc2Cl)CC(=O)N1CCC(c1ccccc1)c1ccccc1

QM31靶点实验

查看更多实验

实验名称：Cytotoxicity against human U937 cells after 24 hrs by MTT assay 来源：ChEMBL 靶标：U-937 External Id：CHEMBL943994

实验名称：Antiapoptotic activity against human A549 cells assessed as inhibition of doxorubicin... 来源：ChEMBL 靶标：A549 External Id：CHEMBL943999

实验名称：Antiapoptotic activity against human Saos2 cells assessed as inhibition of doxycyclin... 来源：ChEMBL 靶标：SAOS-2 External Id：CHEMBL944000

实验名称：Antiapoptotic activity against human Saos2 cells assessed as inhibition of doxycyclin... 来源：ChEMBL 靶标：SAOS-2 External Id：CHEMBL944001

实验名称：Antiapoptotic activity against human U937 cells assessed as inhibition of doxorubicin... 来源：ChEMBL 靶标：U-937 External Id：CHEMBL944002

实验名称：Antiapoptotic activity against human U2OS cells assessed as inhibition of doxorubicin... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL943995

实验名称：Antiapoptotic activity against human U2OS cells assessed as inhibition of doxorubicin... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL943996

实验名称：Antiapoptotic activity against human U937 cells assessed as inhibition of doxorubicin... 来源：ChEMBL 靶标：U-937 External Id：CHEMBL943997

实验名称：Antiapoptotic activity against human HeLa cells assessed as inhibition of doxorubicin... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL943998

实验名称：Inhibition of apoptosome activity in human Saos2 cells assessed as inhibition of casp... 来源：ChEMBL 靶标：SAOS-2 External Id：CHEMBL944007

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