1H-Pyrazolo[3,4-b]pyridine-4-carboxaMide, 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-1-(1-Methylethyl)

• 常用名: 1H-Pyrazolo[3,4-b]pyridine-4-carboxaMide, 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-1-(1-Methylethyl)
• 英文名: 1H-Pyrazolo[3,4-b]pyridine-4-carboxaMide, 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-1-(1-Methylethyl)
• CAS号: 938431-72-2
• 分子量: 473.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₇N₅O₄
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1H-Pyrazolo[3,4-b]pyridine-4-carboxaMide, 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-1-(1-Methylethyl)

物理化学性质

• 分子式: C₂₆H₂₇N₅O₄
• 分子量: 473.5
• InChIKey: PHHBPZAKJMTXPV-UHFFFAOYSA-N
• SMILES: Cc1cc(C)c(CNC(=O)c2cc(-c3ccc4c(c3)OCCO4)nc3c2cnn3C(C)C)c(=O)[nH]1

靶点实验

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实验名称：Inhibition of methyltransferase activity of EZH2 in human G401 cells assessed as H3K2... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL3772958

实验名称：Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL3772956

实验名称：Oral bioavailability in mouse at 10 mg/kg by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3772962

实验名称：Volume of distribution at steady state in mouse at 2 mg/kg, iv and 10 mg/kg, po by LC... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3772961

实验名称：Wild-Type PRC2 Enzyme Assay from US Patent US10273223: "Substituted 6,5-fused bicycli... 来源：BindingDB 靶标：N/A External Id：BindingDB_2836_1

实验名称：AUC in mouse at 2 mg/kg, iv and 10 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3772960

实验名称：Clearance in mouse at 2 mg/kg, iv and 10 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3772959

实验名称：Enzyme Assay from US Patent US9637472: "Substituted 6,5-fused bicyclic heteroaryl com... 来源：BindingDB 靶标：N/A External Id：BindingDB_1480_1

实验名称：Inhibition of EZH2 (unknown origin) 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL5123926

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