VER-49009

• 常用名: VER-49009
• 英文名: VER-49009
• CAS号: 940289-57-6
• 分子量: 387.817
• 密度: 1.4±0.1 g/cm3
• 沸点: 620.2±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈ClN₃O₄
• 熔点: N/A
• 闪点: 328.9±31.5 °C

VER-49009用途

VER-49009 是一种强效的HSP90抑制剂，其IC50为 47 nM。

VER-49009名称

• 中文名: VER-49009
• 英文名: 5-(3-chloro-4-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)-N-ethyl-4-(4-methoxyphenyl)-1,2-dihydropyrazole-3-carboxamide

VER-49009物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 620.2±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈ClN₃O₄
• 分子量: 387.817
• 闪点: 328.9±31.5 °C
• 精确质量: 387.098572
• PSA: 107.47000
• LogP: 0.96
• InChIKey: HUNAOTXNHVALTN-UHFFFAOYSA-N
• SMILES: CCNC(=O)c1[nH]nc(-c2cc(Cl)c(O)cc2O)c1-c1ccc(OC)cc1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.642
• 储存条件: -20℃

VER-49009靶点实验

查看更多实验

实验名称：Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 ... 来源：ChEMBL 靶标：NCI-H1975 External Id：CHEMBL3100553

实验名称：Binding affinity to Hsp90 by fluorescence polarization assay 来源：ChEMBL 靶标：Heat shock protein HSP 90-beta External Id：CHEMBL1020372

实验名称：Displacement of fluorescent labelled VER-00051001 from human Hsp90-beta by FP assay 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL943064

实验名称：Recombinant Hsp90 [His-Tev-huHsp90-alpha (9-236)] was immobilized on a Biacore CM5 ch... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL3885742

实验名称：Growth inhibition of human HCT116 cells after 24 hrs by SRB assay 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL943065

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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VER-49009英文别名

• 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)pyrazole-3-carboxamide
• Kinome_3578
• 3-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
• VER-49009