N-(6-(2-aminopyrimidin-5-yl)-2-morpholinopyrimidin-4-yl)quinolin-3-amine

• 常用名: N-(6-(2-aminopyrimidin-5-yl)-2-morpholinopyrimidin-4-yl)quinolin-3-amine
• 英文名: N-(6-(2-aminopyrimidin-5-yl)-2-morpholinopyrimidin-4-yl)quinolin-3-amine
• CAS号: 944395-98-6
• 分子量: 400.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₀N₈O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(6-(2-aminopyrimidin-5-yl)-2-morpholinopyrimidin-4-yl)quinolin-3-amine

物理化学性质

• 分子式: C₂₁H₂₀N₈O
• 分子量: 400.4
• InChIKey: LICCCQJZOPRJSR-UHFFFAOYSA-N
• SMILES: Nc1ncc(-c2cc(Nc3cnc4ccccc4c3)nc(N3CCOCC3)n2)cn1

靶点实验

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实验名称：Antiproliferative activity against human A2780 cells after 3 days by CellTiter-Glo as... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL2020155

实验名称：Inhibition of PI3K-mediated AKT Ser473 phosphorylation in human A2780 cells after 1 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2020156

实验名称：Inhibition of PI3Kalpha using 1-alpha-phosphatidylinositol as substrate by ATP deplet... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL2020154

实验名称：Half life in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1680111

实验名称：Volume of distribution at steady state in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020159

实验名称：Clearance in rat at 5 mg/kg, iv and 20 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1680112

实验名称：AUC in rat at 20 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1680113

实验名称：Clearance in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020157

实验名称：Volume of distribution at steady state in rat at 5 mg/kg, iv and 20 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1680114

实验名称：AUC in rat at 20 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020158

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