4-Chloro-5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-2-pyridinamine

• 常用名: 4-Chloro-5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-2-pyridinamine
• 英文名: 4-Chloro-5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-2-pyridinamine
• CAS号: 944397-11-9
• 分子量: 376.8
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₁ClN₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-Chloro-5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-2-pyridinamine

物理化学性质

• 分子式: C₁₇H₂₁ClN₆O₂
• 分子量: 376.8
• InChIKey: JKVGJGBIUVYAIV-UHFFFAOYSA-N
• SMILES: Nc1cc(Cl)c(-c2cc(N3CCOCC3)nc(N3CCOCC3)n2)cn1

靶点实验

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实验名称：Oral bioavailability in rat at 20 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020163

实验名称：Intrinsic clearance in rat liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2020167

实验名称：Intrinsic clearance in human liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2020168

实验名称：Solubility of the compound at pH 7 来源：ChEMBL 靶标：N/A External Id：CHEMBL2020166

实验名称：Antiproliferative activity against human A2780 cells after 3 days by CellTiter-Glo as... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL2020155

实验名称：Inhibition of PI3K-mediated AKT Ser473 phosphorylation in human A2780 cells after 1 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2020156

实验名称：Inhibition of PI3Kalpha using 1-alpha-phosphatidylinositol as substrate by ATP deplet... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL2020154

实验名称：Volume of distribution at steady state in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020159

实验名称：Clearance in rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020157

实验名称：AUC in rat at 20 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2020158

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