N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine

• 常用名: N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine
• 英文名: N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine
• CAS号: 948562-88-7
• 分子量: 527.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₀F₃N₇O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine

物理化学性质

• 分子式: C₂₈H₂₀F₃N₇O
• 分子量: 527.5
• InChIKey: VIHXUAKPZPXVSW-UHFFFAOYSA-N
• SMILES: CNc1nccc(-c2cccnc2Oc2ccc(Nc3nc4ccc(C(F)(F)F)cc4[nH]3)c3ccccc23)n1

靶点实验

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实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Selectivity ratio of IC50 for Aurora A to IC50 for Tie2 来源：ChEMBL 靶标：N/A External Id：CHEMBL1120727

实验名称：Selectivity ratio of IC50 for Aurora B to IC50 for Tie2 来源：ChEMBL 靶标：N/A External Id：CHEMBL1120726

实验名称：Inhibition of Tie2 来源：ChEMBL 靶标：Angiopoietin-1 receptor External Id：CHEMBL1120725

实验名称：Inhibition of LCK 来源：ChEMBL 靶标：Tyrosine-protein kinase Lck External Id：CHEMBL1120724

实验名称：Inhibition of KDR 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL1120723

实验名称：Inhibition of Aurora A 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL1120722

实验名称：Inhibition of Aurora B 来源：ChEMBL 靶标：Aurora kinase B External Id：CHEMBL1120721

实验名称：Inhibition of KDR 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL1029839

实验名称：Inhibition of Tie2 at 1 uM relative to control 来源：ChEMBL 靶标：Angiopoietin-1 receptor External Id：CHEMBL1120734

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