(2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-2-methyl-4-(4,4,4-trifluorobutyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one

• 常用名: (2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-2-methyl-4-(4,4,4-trifluorobutyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one
• 英文名: (2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-2-methyl-4-(4,4,4-trifluorobutyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one
• CAS号: 949009-66-9
• 分子量: 521.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₄F₅N₅O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-2-methyl-4-(4,4,4-trifluorobutyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one

物理化学性质

• 分子式: C₂₅H₂₄F₅N₅O₂
• 分子量: 521.5
• InChIKey: UERMDDSMFCIPGD-DEOSSOPVSA-N
• SMILES: CCC1=C(C(=NC(=N1)N)N)C2=CC3=C(C=C2)O[C@@](C(=O)N3CCCC(F)(F)F)(C)C4=CC(=CC(=C4)F)F

靶点实验

查看更多实验

实验名称：Half life in rat at 1 mg/kg, iv or 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL898593

实验名称：Half life in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1285381

实验名称：Half life in dog 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1285382

实验名称：Clearance in rat at 1 mg/kg, iv or 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL898591

实验名称：Volume of distribution at steady state in rat at 1 mg/kg, iv or 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL898592

实验名称：Metabolic stability in human liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL898575

实验名称：Bioavailability in dog at 5 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL898601

实验名称：Inhibition of human recombinant renin in buffer 来源：ChEMBL 靶标：Renin External Id：CHEMBL1285355

实验名称：Bioavailability in rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL898602

实验名称：Oral bioavailability in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1285361

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