4-(2,4-Difluoroanilino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide

• 常用名: 4-(2,4-Difluoroanilino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide
• 英文名: 4-(2,4-Difluoroanilino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide
• CAS号: 953798-95-3
• 分子量: 441.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₅F₂N₅O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-(2,4-Difluoroanilino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide

物理化学性质

• 分子式: C₂₃H₂₅F₂N₅O₂
• 分子量: 441.5
• InChIKey: IBHNEKVLDKCEQY-UHFFFAOYSA-N
• SMILES: CCOc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1N1CCN(C)CC1

靶点实验

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实验名称：Inhibition of CSF1R (unknown origin) 来源：ChEMBL 靶标：Macrophage colony-stimulating factor 1 receptor External Id：CHEMBL5524445

实验名称：Aqueous solubility of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1025519

实验名称：Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hr... 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL1025518

实验名称：Cardiotoxicity in beagle dog ventricular cardiomyocyte assessed as reduction in actio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2411822

实验名称：Inhibition of phosphorylated CSF1R level in 3T3/CSF1R mutant cells xenografted nude m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1025525

实验名称：Half life in rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1025524

实验名称：Inhibition of human ERG 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL1025527

实验名称：Inhibition of phosphorylated CSF1R level in 3T3/CSF1R mutant cells xenografted nude m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1025526

实验名称：Bioavailability in rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1025521

实验名称：Plasma protein binding assessed as percentage unbound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1025520

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