Prednicarbate

Prednicarbate Structure
Prednicarbate structure
Common Name Prednicarbate
CAS Number 73771-04-7 Molecular Weight 488.570
Density 1.3±0.1 g/cm3 Boiling Point 640.7±55.0 °C at 760 mmHg
Molecular Formula C27H36O8 Melting Point 110 - 112ºC
MSDS N/A Flash Point 209.4±25.0 °C

Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective.

J. Cancer Res. Clin. Oncol. 139(10) , 1667-72, (2013)

Treatment with cetuximab is accompanied by the development of an acneiform follicular skin exanthema in more than 80 % of patients. Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or cessatio...

Drug release and skin penetration from solid lipid nanoparticles and a base cream: a systematic approach from a comparison of three glucocorticoids.

Skin Pharmacol. Physiol. 24(4) , 199-209, (2011)

Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), predn...

Efficacy of crisis intervention treatment with topical corticosteroid prednicarbat with and without partial wet-wrap dressing in atopic dermatitis.

Dermatology 212(1) , 66-9, (2006)

The wet-wrap treatment has been reported to be beneficial in acute episodes of atopic dermatitis (AD) skin lesions.The efficacy of topical corticosteroid prednicarbat with and without additional wet-wrap dressing was investigated in a prospective, randomized ...

Transcriptional activity of potent glucocorticoids: relevance of glucocorticoid receptor isoforms and drug metabolites.

Skin Pharmacol. Appl. Skin Physiol. 16(3) , 143-50, (2003)

As compared to standard glucocorticoids (GC), prednicarbate (PC) is favorable in the treatment of eczema due to its high benefit/risk ratio. The remarkable anti-inflammatory effects of PC are in strong contrast to its reported low glucocorticoid receptor (GR)...

Steroid-sparing effect of pimecrolimus cream 1% in children with severe atopic dermatitis.

Dermatology 215(4) , 325-30, (2007)

To investigate if pimecrolimus cream 1% reduces the need for steroids in the long-term management of severe pediatric atopic dermatitis (AD).A total of 184 pediatric patients (aged 2-17 years) with a history of severe AD according to Rajka and Langeland were ...

Modern topical glucocorticoids and anti-infectives for superinfected atopic eczema: do prednicarbate and didecyldimethylammoniumchloride form a rational combination?

Infection 22(6) , 390-4, (1994)

The addition of an anti-infective to a topical glucocorticoid preparation for superinfected atopic eczema is still controversial. To address this question in the context of the topical glucocorticoids of the non-halogenated double-ester type 0.25% prednicarba...

Atopic dermatitis -- topical therapy: do patients apply much too little?

J. Dermatolog. Treat. 16(2) , 95-101, (2005)

The treatment of atopic dermatitis still remains a challenge. Little research has been done on the issue of the extent to which patients correctly use prescribed topical preparations under everyday conditions.To investigate what quantity of topical preparatio...

Purpuric generalized lichen nitidus: an unusual eruption simulating pigmented purpuric dermatosis.

Dermatology 208(2) , 167-70, (2004)

Generalized haemorrhagic lichen nitidus is rare. To our knowledge, this form of presentation has only been reported once.To describe a new case of generalized haemorrhagic lichen nitidus simulating a pigmented purpuric dermatosis.We document a 24-year-old man...

[Mollusca contagiosa in an infant with atopic eczema. A therapeutic challenge].

Hautarzt 55(10) , 991-4, (2004)

Molluscum contagiosum is a viral disease frequently observed in children and adolescents with atopic dermatitis, in whom it poses a special therapeutic challenge. A 3-year-old girl presented with atopic eczema and disseminated molluscum contagiosum on her but...

Grover's disease associated with pregnancy.

J. Dermatol. 37(4) , 381-3, (2010)