Optimisation of conoidin A, a peroxiredoxin inhibitor

…, JAG Walton, G Xu, AMZ Slawin, NJ Westwood

Index: Liu, Gu; Botting, Catherine H.; Evans, Kathryn M.; Walton, Jeffrey A. G.; Xu, Guogang; Slawin, Alexandra M. Z.; Westwood, Nicholas J. ChemMedChem, 2010 , vol. 5, # 1 p. 41 - 45

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Citation Number: 17

Abstract

We recently reported that conoidin A (1)(Scheme 1) inhibits the function of the peroxiredoxin TgPrxII,[1] an understudied protein from the apicomplexan parasite Toxoplasma gondii.[2] 1 targets TgPrxII both in vitro and in live parasites and also inhibits the hyperoxidation of two mammalian peroxiredoxin homologues (PrxI and PrxII) in cells.[2] As the biology and chemistry associated with mammalian peroxiredoxins has entered a new phase, with the ...