Tetrahedron Letters

N-Methoxy-N-methylamides as effective acylating agents

S Nahm, SM Weinreb

Index: Nahm, Steven; Weinreb, Steven M. Tetrahedron Letters, 1981 , vol. 22, # 39 p. 3815 - 3818

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Citation Number: 1591

Abstract

... N-METHOXY-N-METHYLAMIDES AS EFFECTIVE ACYLATING AGENTS Steven Nahm and Steven M. Weinreb* Department of Chemistry The Pennsylvania State University University Park, PA 16802 Summary: Readily preparable N-methoxy-N-methylamides couple in good yields with Grignard and organolithium reagents to produce ketones, and are reduced with hydrides to afford aldehydes. ...