Synlett

Zirconyl Chloride: An Efficient, Water-Tolerant, and Reusable Catalyst for the Synthesis of N-Methylamides

D Talukdar, L Saikia, AJ Thakur

Index: Talukdar, Dhrubajyoti; Saikia, Lakhinath; Thakur, Ashim Jyoti Synlett, 2011 , # 11 p. 1597 - 1601

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Citation Number: 9

Abstract

Abstract ZrOCl 2 8H 2 O is a highly effective, water-tolerant, and reusable catalyst for the direct condensation of carboxylic acids and N, N′-dimethylurea under microwave irradiation to give the corresponding N-methylamides in moderate to excellent yields. Notably, ZrOCl 2 8H 2 O is a potentially useful green catalyst due to its low toxicity, easy availability, low cost, ease of handling, easy recovery, good activity, and reusability.