Synthetic Communications®

Facile one-pot conversion of aldehydes into amides

ST Chill, RC Mebane

Index: Chill, Samuel T.; Mebane, Robert C. Synthetic Communications, 2010 , vol. 40, # 13 p. 2014 - 2017

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Citation Number: 9

Abstract

A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100° C and the subsequent treatment of the nitrile with basic hydrogen peroxide. The resulting amide products were produced in good yields (67–95%) and purity (> 95%).