Efficient synthesis of azetidine through N??trityl??or N??dimethoxytritylazetidines starting from 3??amino??l??propanol or 3??halopropylamine hydrohalides

P Huszthy, JS Bradshaw, KE Krakowiak…

Index: Huszthy; Bradshaw; Krakowiak; Wang; Dalley Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1197 - 1207

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Citation Number: 19

Abstract

Abstract Efficient synthetic routes for the preparation of azetidine starting from commercially available 3-amino-l-propanol or 3-halopropylamine hydrohalides are reported. First, the appropriate N-trityl-or N-dimethoxy-trityl protected tosyloxy-or halopropylamines were prepared. These precursors were then cyclized into the N-trityl-or N- dimethoxytritylazetidines. The N-protecting groups were removed in the presence of ...