Iridium-Catalyzed Alkylation of Methylquinolines with Alcohols

Y Obora, S Ogawa, N Yamamoto

Index: Obora, Yasushi; Ogawa, Shinji; Yamamoto, Nobuyuki Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9429 - 9433,5

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Citation Number: 30

Abstract

Iridium-catalyzed alkylation of methylquinolines at the methyl substituent was achieved using alcohols as alkylating agents. The reaction proceeded through a transfer hydrogenation pathway from the alcohol to the Ir complex, affording an aldehyde and Ir–H species, followed by base-assisted aldol condensation and hydrogenation. This method provides an atom-economical and convenient route to alkylquinolines from easily ...