The synthesis and biophysical investigations of novel ring-expanded nucleosides, nucleotides, and homopolymers containing the 5: 7-fused heterocyclic ring system, …

…, RL Karpel, U Siriwardane, NS Hosmane

Index: Hosmane, Ramachandra S.; Bhan, Anila; Karpel, Richard L.; Siriwardane, Upali; Hosmane, Narayan S. Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5882 - 5890

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Citation Number: 28

Abstract

The synthesis and conformational studies of two isomeric 5: 7-fused nucleosides, 4, 5, 7, 8- tetrahydro-6H-3-(@~-ribofuranosyl) imidazo [4, 5-e][1, 4] diazepine-5, &dione (1) and its 1- glycosyl analogue (2), their respective 5'-monoand-diphosphate derivatives (13 and 14), and the corresponding homopolymers (15 and 16) are presented. While 1 is devoid of activity against murine leukemia virus (MuLV) in tissue culture systems, 2 is as active as ...