Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1, 3, 4-thiadiazole derivatives

AA Kadi, ES Al-Abdullah, IA Shehata, EE Habib…

Index: Kadi, Adnan A.; Al-Abdullah, Ebtehal S.; Shehata, Ihsan A.; Habib, Elsayed E.; Ibrahim, Tarek M.; El-Emam, Ali A. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5006 - 5011

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Citation Number: 103

Abstract

New 1-adamanyl-1, 3, 4-thiadiazole derivatives namely, 5-(1-adamantyl)-1, 3, 4- thiadiazoline-2-thione 3, 5-(1-adamantyl)-3-(benzyl-or 4-substituted benzyl)-1, 3, 4- thiadiazoline-2-thione 4a–d, 5-(1-adamantyl)-3-(4-substituted-1-piperazinylmethyl)-1, 3, 4- thiadiazoline-2-thiones 5a–c, 2-[5-(1-adamantyl)-2-thioxo-1, 3, 4-thiadiazolin-3-yl] acetic acid 7,(±)-2-[5-(1-adamantyl)-2-thioxo-1, 3, 4-thiadiazolin-3-yl] propionic acid 9, 3-[5-(1- ...