Tetrahedron Letters

Rapid synthesis of 2, 3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide

IK Kostakis, A Elomri, E Seguin, M Iannelli, T Besson

Index: Kostakis, Ioannis K.; Elomri, Abdelhakim; Seguin, Elisabeth; Iannelli, Mauro; Besson, Thierry Tetrahedron Letters, 2007 , vol. 48, # 38 p. 6609 - 6613

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Citation Number: 41

Abstract

An efficient methodology for the preparation of a series of 2, 3-disubstituted-quinazolin-4 (3H)-ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4 (3H)-ones and other rings.