Tetrahedron

A palladium-catalyzed synthesis of isatins (1H-Indole-2, 3-diones) from 1-(2-haloethynyl)-2-nitrobenzenes

BCG Söderberg, SP Gorugantula, CR Howerton…

Index: Soederberg, Bjoern C.G.; Gorugantula, Sobha P.; Howerton, Chet R.; Petersen, Jeffrey L.; Dantale, Shubhada W. Tetrahedron, 2009 , vol. 65, # 36 p. 7357 - 7363

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Citation Number: 12

Abstract

An inherently regiospecific synthesis of isatins (1H-indole-2, 3-diones) starting from 1-halo-2- nitrobenzenes is described. The isatins are formed by an intramolecular palladium- catalyzed annulation of 2-(2-haloethynyl)-1-nitrobenzenes via the formation of 2- haloisatogens.