N*-N*-S* tridentate ligand system as potential antitumor agents

…, G Cristalli, P Franchetti, M Grifantini…

Index: Antonini, Ippolito; Claudi, Francesco; Cristalli, Gloria; Franchetti, Palmarisa; Grifantini, Mario; Martelli, Sante Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1181 - 1184

Full Text: HTML

Citation Number: 48

Abstract

The 2, 2'-bipyridyl-6-carbonitrile (6) was prepared by reacting 2, 2'-bipyridyll-oxide (5) with sodium cyanide and benzoyl chloride in water; 5 was synthesized by oxidizing 2, 2'-bipyridyl with H202 in AcOH (Scheme 11). This method gave a higher total yield and used fewer steps than the one described by Case. lo

 Related Synthetic Route
2,2'-Bipyridine Structure

366-18-7

2,2'-Bipyridine

~%

[2,2'-Bipyridine]-6-carbothioamide Structure

78797-02-1

[2,2'-Bipyridin...

Thiosemicarbazide Structure

79-19-6

Thiosemicarbazide

6-(diacetoxymethyl)pyridine-2-carbothioamide Structure

78797-07-6

6-(diacetoxymet...

~70%

6-[(carbamothioylhydrazinylidene)methyl]pyridine-2-carbothioamide Structure

78797-11-2

6-[(carbamothio...

2-cyano-6-(diacetoxymethyl)pyridine Structure

78797-06-5

2-cyano-6-(diac...

~%

6-[(carbamothioylhydrazinylidene)methyl]pyridine-2-carbothioamide Structure

78797-11-2

6-[(carbamothio...

6-(diacetoxymethyl)pyridine-2-carbothioamide Structure

78797-07-6

6-(diacetoxymet...

~45%

2-Pyridinecarbothioamide,6-formyl- Structure

78797-08-7

2-Pyridinecarbo...

2-cyano-6-(diacetoxymethyl)pyridine Structure

78797-06-5

2-cyano-6-(diac...

~%

2-Pyridinecarbothioamide,6-formyl- Structure

78797-08-7

2-Pyridinecarbo...

2-cyano-6-(diacetoxymethyl)pyridine Structure

78797-06-5

2-cyano-6-(diac...

~%

2-Pyridinecarbothioamide,6-[(phenylimino)methyl]- Structure

78797-13-4

2-Pyridinecarbo...

6-(diacetoxymethyl)pyridine-2-carbothioamide Structure

78797-07-6

6-(diacetoxymet...

Structure

74497-02-2

~31%

2-Pyridinecarbothioamide,6-[(phenylimino)methyl]- Structure

78797-13-4

2-Pyridinecarbo...

N/A Structure

4426-72-6

N/A

6-(diacetoxymethyl)pyridine-2-carbothioamide Structure

78797-07-6

6-(diacetoxymet...

~71%

Hydrazinecarboxamide,2-[[6-(aminothioxomethyl)-2-pyridinyl]methylene]- Structure

78797-10-1

Hydrazinecarbox...

2-cyano-6-(diacetoxymethyl)pyridine Structure

78797-06-5

2-cyano-6-(diac...

~%

Hydrazinecarboxamide,2-[[6-(aminothioxomethyl)-2-pyridinyl]methylene]- Structure

78797-10-1

Hydrazinecarbox...

6-Cyano-2,2'-bipyridine Structure

4392-85-2

6-Cyano-2,2'-bi...

Dimethylamine Structure

124-40-3

Dimethylamine

~50%

[2,2'-Bipyridine]-6-carbothioamide,N,N-dimethyl- Structure

78797-04-3

[2,2'-Bipyridin...

2,2'-Bipyridine Structure

366-18-7

2,2'-Bipyridine

~%

[2,2'-Bipyridine]-6-carbothioamide,N,N-dimethyl- Structure

78797-04-3

[2,2'-Bipyridin...

2 2'-dipyridyl-n-oxide 98 Structure

33421-43-1

2 2'-dipyridyl-...

~%

[2,2'-Bipyridine]-6-carbothioamide,N,N-dimethyl- Structure

78797-04-3

[2,2'-Bipyridin...

Phenylhydrazine hydrochloride Structure

59-88-1

Phenylhydrazine...

6-(diacetoxymethyl)pyridine-2-carbothioamide Structure

78797-07-6

6-(diacetoxymet...

~63%

2-Pyridinecarbothioamide,6-[(2-phenylhydrazinylidene)methyl]- Structure

78797-12-3

2-Pyridinecarbo...

2-cyano-6-(diacetoxymethyl)pyridine Structure

78797-06-5

2-cyano-6-(diac...

~%

2-Pyridinecarbothioamide,6-[(2-phenylhydrazinylidene)methyl]- Structure

78797-12-3

2-Pyridinecarbo...

6-Cyano-2,2'-bipyridine Structure

4392-85-2

6-Cyano-2,2'-bi...

methylamine Structure

74-89-5

methylamine

~79%

[2,2'-Bipyridine]-6-carbothioamide,N-methyl- Structure

78797-03-2

[2,2'-Bipyridin...

2,2'-Bipyridine Structure

366-18-7

2,2'-Bipyridine

~%

[2,2'-Bipyridine]-6-carbothioamide,N-methyl- Structure

78797-03-2

[2,2'-Bipyridin...

2 2'-dipyridyl-n-oxide 98 Structure

33421-43-1

2 2'-dipyridyl-...

~%

[2,2'-Bipyridine]-6-carbothioamide,N-methyl- Structure

78797-03-2

[2,2'-Bipyridin...

(3-oxobutan-2-ylideneamino)thiourea Structure

7274-56-8

(3-oxobutan-2-y...

Phenylhydrazine Structure

100-63-0

Phenylhydrazine

~62%

[[(3Z)-3-(phenylhydrazinylidene)butan-2-ylidene]amino]thiourea Structure

78797-15-6

[[(3Z)-3-(pheny...

6-(diacetoxymethyl)pyridine-2-carbothioamide Structure

78797-07-6

6-(diacetoxymet...

~76%

2-Pyridinecarbothioamide,6-[(hydroxyimino)methyl]- Structure

78797-09-8

2-Pyridinecarbo...

2-cyano-6-(diacetoxymethyl)pyridine Structure

78797-06-5

2-cyano-6-(diac...

~%

2-Pyridinecarbothioamide,6-[(hydroxyimino)methyl]- Structure

78797-09-8

2-Pyridinecarbo...


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