Tetrahedron letters

[2.2] PHANEPHOS-Ruthenium (II) complexes: Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

…, K Rossen, RA Reamer, RP Volante, PJ Reider

Index: Pye, Philip J.; Rossen, Kai; Reamer, Robert A.; Volante; Reider, Paul J. Tetrahedron Letters, 1998 , vol. 39, # 25 p. 4441 - 4444

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Citation Number: 116

Abstract

The application of the planar chiral [2.2] PHANEPHOS ligand in the Ru (II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2] PHANEPHOS-Ru (II) bis (trifluoroacetate) salt in the presence of a halide source.