Design, synthesis, and preclinical evaluations of novel 4-substituted 1, 5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug …

LQ Sun, L Zhu, K Qian, B Qin, L Huang…

Index: Piersanti, Giovanni; Giorgi, Luca; Bartoccini, Francesca; Tarzia, Giorgio; Minetti, Patrizia; Gallo, Grazia; Giorgi, Fabrizio; Castorina, Massimo; Ghirardi, Orlando; Carminati, Paolo Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2567 - 2571

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Citation Number: 39

Abstract

... 2012, 55 (16), pp 7219–7229. DOI: 10.1021/jm3007678. Publication Date (Web): August 2, 2012. Copyright © 2012 American Chemical Society. ... Chemistry. ... Therefore, we postulated that an electron-withdrawing R 1 group with appropriate volume and length on the B-ring might be ...