Tetrahedron letters

Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno [2, 3-d] pyrimidin-4-one and 4-chlorothieno [2, 3-d] pyrimidine

S Hesse, E Perspicace, G Kirsch

Index: Hesse, Stephanie; Perspicace, Enrico; Kirsch, Gilbert Tetrahedron Letters, 2007 , vol. 48, # 30 p. 5261 - 5264

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Citation Number: 74

Abstract

2-Aminothiophenes have demonstrated a broad spectrum of uses including pharmaceuticals, 1 dyes and agrochemical applications. Traditionally, polysubstituted 2-aminothiophenes with an electron-withdrawing group such as cyano, carbethoxy or carboxamide in the 3-position and alkyl, aryl or hetaryl groups in the 4- and 5-positions are prepared via the Gewald reaction. 2 There are two common variations on this synthesis: a one-pot procedure in ...