Rh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza??Dihydrodibenzoxepines

AA Friedman, J Panteleev, J Tsoung…

Index: Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758

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Citation Number: 40

Abstract

Domino catalysis is an ideal strategy in the synthesis of heterocyclic scaffolds, as multiple bonds can be formed under a single set of reaction conditions. Beyond the rapid generation of molecular complexity, time and cost efficiencies resulting from the lack of purification of intermediates make such methods attractive. To this end, various permutations of domino metal-, organo-, and bio-catalyzed methods have been developed,[1] including several ...