Cobalt??Catalyzed Cross??Coupling Reactions of Alkyl Halides with Allylic and Benzylic Grignard Reagents and Their Application to Tandem Radical Cyclization/Cross …

H Ohmiya, T Tsuji, H Yorimitsu…

Index: Ohmiya, Hirohisa; Tsuji, Takashi; Yorimitsu, Hideki; Oshima, Koichiro Chemistry - A European Journal, 2004 , vol. 10, # 22 p. 5640 - 5648

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Citation Number: 98

Abstract

Abstract Details of cobalt-catalyzed cross-coupling reactions of alkyl halides with allylic Grignard reagents are disclosed. A combination of cobalt (II) chloride and 1, 2-bis (diphenylphosphino) ethane (DPPE) or 1, 3-bis (diphenylphosphino) propane (DPPP) is suitable as a precatalyst and allows secondary and tertiary alkyl halides—as well as primary ones—to be employed as coupling partners for allyl Grignard reagents. The reaction offers ...