Journal of medicinal chemistry

Synthesis and. beta.-adrenergic antagonist activity of stereoisomeric practolol and propranolol derivatives

K Leftheris, M Goodman

Index: Leftheris, Katerina; Goodman, Murray Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 216 - 223

Full Text: HTML

Citation Number: 18

Abstract

A series of stereoisomeric practolol and propranolol derivatives has been synthesized in which the N-isopropyl group of the drug was replaced by an asymmetric heptanoic acid terminated by a substituted p-toluidide or p-(trifluoromethy1) anilide. The asymmetric epoxide, 3-(p-acetamidophenoxy)-1, 2-epoxypropane, was allowed to react with a preformed enantiomeric 6-aminoheptanoic acid amide to yield the stereoisomeric ...

~79%

Mild, versatile, and chemoselective indium (III) triflate-ca...

[Golden, Kathryn C.; Gregg, Brian T.; Quinn, John F. Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4010 - 4013]

Synthesis of optically active lipopeptide analogs from the o...

[Kurimura; Takemoto; Achiwa Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2590 - 2596]

Absolute configuration of glycerol derivatives. 3. Synthesis...

[Nelson,W.L. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 1006 - 1012]

Synthesis and activity of optical isomers of nipradilol.

[Shiratsuchi; Kawamura; Akashi; Ishihama; Nakamura; Takenaka Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 9 p. 3691 - 3698]

Asymmetric enzymatic hydrolysis of prochiral 2-O-allylglycer...

[Wirz, Beat; Schmid, Rudolf; Foricher, Joseph Tetrahedron: Asymmetry, 1992 , vol. 3, # 1 p. 137 - 142]