Cyclodehydration of N-and C-substituted. beta.-amino alcohols to the corresponding aziridines with diethoxytriphenylphosphorane

JW Kelly, NL Anderson, SA Evans Jr

Index: Kelly, Jeffery W.; Eskew, Nita L.; Evans, Slayton A. Journal of Organic Chemistry, 1986 , vol. 51, # 1 p. 95 - 97

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Citation Number: 57

Abstract

The growing importance of functionalized aziridines in organic synthesis' and their presence in numerous biomolecules2 suggest that a general synthetic procedure leading to C-and N- substituted aziridines under essentially neutral conditions would be attractive. The availability of such a procedure coupled with readily accessible, enantiomerically homogeneous@-amino alcohols from optically pure a-amino acids3 would also serve to ...