European journal of medicinal chemistry

Inhibitory effect of synthetic aminophosphonic acid derivatives on human carbonic anhydrase

G Ösapay, A Csiba

Index: Oesapay, G; Csiba, A European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 355 - 361

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Citation Number: 6

Abstract

Abstract A series of phosphonic analogs of amino acids, peptides and their derivatives was synthesized in order to examine their ability to inhibit human carbonic anhydrase (HCA) isoenzymes (I and II). The aminophosphonic acids with amino protection possess much stronger inhibitory capacity (K i= 10− 6-10− 5 M) than the free aminophosphonic acids (K i= 10− 5-10− 3 M). The aminophosphonic acids with both N-and P-protection do not have an ...