Studies on imidazole derivatives and related compounds. I. Synthesis of novel antineoplastic derivatives of 4??carbamoylimidazolium??5??olate

Y Tarumi, Y Takebayashi, K Moriguchi…

Index: Tarumi; Takebayashi; Moriguchi; et al. Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 7 p. 1425 - 1433

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Citation Number: 7

Abstract

Abstract Acylation of 4-carbamoylimidazolium-5-olate (2) with a variety of acid chlorides produced 4 (5)-carbamoyl-1H-imidazol-5-(4) yl acid carboxylates (3a-j). Treatment of esters 3a, c with sodium hydroxide gave imides, 4a, c. Methylation of 3a and 2 with diazomethane gave the N-3 methyl derivative (6) and a mixture of the N-3, O-dimethyl derivative (9), the N- 1, N-3-dimethyl derivative (10) and the O-methyl derivative (11), respectively. 5- ...